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The Department of Infectious Diseases, Virology at the University Hospital Heidelberg, Germany offers a position for a PhD student working on Dynamics of HIV-1 post-entry events in the group of Prof. Dr. Barbara Müller.


The interaction of human immunodeficiency virus with its host cell involves numerous highly dynamic steps that are difficult or impossible to investigate by classical approaches. Therefore, our group applies advanced imaging techniques to study dynamic events in HIV-1 assembly at the plasma membrane and in early post-entry stages of HIV-1 replication. In this project, we specifically focus on HIV-1 cell-cell transmission and post-entry stages of HIV-1 replication with a focus on dynamic aspects. These processes are complex and require tight regulation in space and time; post-entry events are further influenced by numerous host cell restriction and dependency factors. For their investigation, we establish and apply a variety of state of the art fluorescence labeling technologies and live-cell imaging, complemented by standard virological and cell biological methods and novel biochemical approaches.


We offer an interesting, interdisciplinary research topic with biomedical relevance in an interactive scientific environment, including collaborations with national and international partners, at an internationally competitive level. The lab is located in the new Centre for Integrative Infectious Disease Research, which also houses the state-of-the-art IDIP imaging platform. The student will be a member of the SFB1129 ( Successful candidates have the possibility to apply for the HBIGS International Graduate School to fully benefit from the excellent scientific training of this program.


Applicants should have a Masters degree (biology, biochemistry, possibly biophysics or molecular medicine). They should be interested in addressing basic virological questions using different methods with a strong focus on imaging techniques. A good background in standard molecular biological methods is expected. Ideal candidates would already have some experience in fluorescence microscopy and image analysis, together with a background in cell biology, biochemistry or biophysics.


We are looking forward to meet curious and motivated students who are really enthusiastic about science. They should enjoy working independently, but also love to interact, discuss and collaborate with scientists from different disciplines and nations.





Bejarano et al. (2019) HIV-1 nuclear import in macrophages is regulated by CPSF6-capsid interactions at the Nuclear Pore Complex. Elife 8. pii: e41800. doi: 10.7554/eLife.41800


Sakin et al. (2017). A versatile tool for live-cell imaging and super-resolution nanoscopy studies of HIV-1 Env distribution and mobility. Cell Chem Biol. 24:635-645.e5


Hanne et al. (2016). Stimulated Emission Depletion Nanoscopy Reveals Time-Course of Human Immunodeficiency Virus Proteolytic Maturation. ACS Nano. 10(9):8215-22.


Eckhardt et al. (2011) A SNAP-tagged derivative of HIV-1--a versatile tool to study virus-cell interactions. PLoS One. 2011;6(7):e22007. doi: 10.1371/journal.pone.0022007. Epub 2011 Jul 22.






Müller et al. (2019). A Spotlight on Viruses - Application of Click Chemistry to Visualize Virus-Cell Interactions. Molecules ;24(3). pii: E481. doi: 10.3390/molecules24030481


Sakin et al. (2016). Labeling of virus components for advanced, quantitative image analyses FEBS L 590:1858-1876


Hanne et al. (2016) Super-resolved insights into human immunodeficiency virus biology. (2016) FEBS Lett. doi: 10.1002/1873-3468.12186


Please apply through the HBIGS graduate school programme